HRT – Hormone Replacement Therapy

What are the Risks & Side Effects of Prometrium?

by Magnolia on August 24, 2013

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Prior to my taking Prometrium, an FDA approved, bioidentical, oral progesterone, I used bioidentical progesterone in a cream form, which I purchased from compounding pharmacies.

I was careful to only purchase the highest grade and quality I could find (read: expensive), and used it happily for several years with no negative side-effects.

Last year, on the advice of my academic mentor, also a women’s health and medical writer, I decided to ask my physician for a prescription of Prometrium. Another motivating factor for me trying Prometrium was that given it is FDA approved, it is also covered by my insurance plan.

In my research over the years, I’ve never run across any studies citing negative side-effects or risks associated with bioidentical progesterone. In fact, most of what I’ve ever read has been positive, and even emphasized the lack of research pointing to serious risks or side effects.

So imagine my surprise when I recently learned that the list of known side-effects and risks associated with Prometrium is actually very long. Given my positive experience with bioidentical progesterone, I was blithely unaware, and truly blissful in my ignorance.

So for all of you faithful and loyal readers who have relied on me for accurate and trustworthy information regarding perimenopause, and treatments for the symptoms of perimenopause, I offer my most humble apologies. Frankly, I should have known, and provided this information sooner. But, like you, I’m continuing to learn and expand my knowledge of perimenopause. And so, in the words of my favorite poet, Maya Angelou, “when you know better, you do better.”

Because this list is so long, I will not write them all out for you in this post. Instead, I will provide the link to the website at the end of this post, and let you check them out for yourself.

But, before you trot off to read the list, I would like to point something out which I think is very important to understand.  There was a time in our medical system when physicians and pharmaceutical companies were not required to disclose every known possible side-effect or risk associated with a drug.

In addition, given that physicians were usually privy to the studies and research associated with the drugs, they had the discretion to determine which side-effects and risks were relevant to discuss with their patients and which were not.

Since then, and more specifically, in the past fifty years or so, consumer protection laws have been implemented which require that all known risks and side-effects, even the most remote or negligible, be disclosed to consumers.

Bearing this in mind, you should discuss any and all concerns you might have with your physician or healthcare provider to determine if Prometrium is right for you. For me personally, I have only experienced positive benefits from using Prometrium, and I have no plans in my near future to stop using it.

You can find the list of known risks and side-effects associated with Prometrium, here at


Great Job Cutting Through the Noise!

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He said in response to my recent post at….”If Menopause is a Natural Process, Why Use Hormones?” “He” is Dr. Steven Rabin, M.D., a Burbank, California gynecologist – and I did appreciate the support and enthusiastic thumbs-up for my article. It’s always good when members of the medical community offer kudos. I just don’t [...]

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The Hormone Decision

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I purchased a new book recently, The Hormone Decision, by Tara Parker-Pope.  Tara is a nationally recognized women’s health writer for both The New York Times and The Wall Street Journal. She was also a contributor in the movie “Hot Flash Havoc: a movie of menopausal proportions” which I viewed recently, and blogged about here. [...]


Hot Flash Havoc: A New Film on Menopause

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There is a new movie out which is making the rounds on the Internet. It is called “Hot Flash Havoc: a film of menopausal proportions.”    One of the co-creators of the film contacted me several weeks ago, and asked me if I would view the film, and consider becoming an affiliate to help promote [...]


Estrogen Replacement Therapy: Yes or No?

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Let’s face it.  The average women does not understand the role of estrogen during perimenopause.  But, when the average OB/GYN doesn’t seem to understand it very well either, is it any surprise then that women looking for help for their symptoms of perimenopause are clueless? It also doesn’t help that there is a big, wide [...]

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Are Compounding Pharmacies Safe?

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Thanks to the recent outbreak of fungal meningitis in the United States, which is now responsible for 25 deaths across the country, compounding pharmacies are now in the cross-hairs of federal regulators, and questions are being raised about their safety. The New England Compounding Center, (NECC), located in Massachusetts, shipped thousands of vials of a [...]

October 29, 2012 CONTINUE READING →

The Benefits of Bioidentical Progesterone in Perimenopause

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Today’s post is a sponsored post by Dr. Wade Huey, a Houston based physician for Body LogicMD.  Dr. Huey specializes in bioidentical hormone replacement therapy.  Please find his bio at the end of the post. Perimenopause is the difficult time when hormones start to decline, but they are not quite low enough for a woman [...]

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Does Estrogen Cause Breast Cancer? Part III

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This is the final post in Dr. Joseph Mazzei’s series on the relationship between estrogen therapy and breast cancer.    If you wish to contact Dr. Mazzei or any of his colleagues in the Body Logic medical group, please see his byline at the end of the post.  As always, the views expressed in this post [...]

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Does Estrogen Cause Breast Cancer? Part II

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Today’s post is a continuation of  Dr. Joseph Mazzei’s post on the relationship between estrogen therapy and breast cancer.  The views expressed in this post are not necessarily the views held by The Perimenopause Blog and are for informational purposes only. Please see your physician or healthcare provider for personal medical evaluations.  Let us continue our conversation from [...]

July 18, 2012 CONTINUE READING →

Does Estrogen Cause Breast Cancer? Part I

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Today’s post is a guest post by Dr. Joseph Mazzei, a Chicago based doctor for BodyLogicMD, a medical group which sponsors The Perimenopause Blog. I asked Dr. Mazzei if he could give his opinion on estrogen therapy since it is starting to make its way back into the news once again.  In this post, Dr. Mazzei [...]

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Testosterone Pellet Therapy

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I wrote a post a couple of weeks ago entitled Bioidentical Testosterone Therapy.  Regular readers and subscribers have read it by now, I’m sure. I shared my experience at Dr. Rebecca Glaser’s office where I received testosterone pellet implants to help with my perimenopause symptoms. Because I have suffered with horrible muscle and joint pain [...]

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